A mutation analysis of theBRCA1gene in 140 families from southeast France with a history of breast and/or ovarian cancer
β Scribed by Philippe Rostagno; Jeanine Gioanni; Eliane Garino; Pierre Vallino; Moise Namer; Marc Frenay
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 200 KB
- Volume
- 48
- Category
- Article
- ISSN
- 1435-232X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Germβline mutations within __BRCA1__ are responsible for different proportions of inherited susceptibility to breast/ovarian cancer, and the spectrum of mutations within this gene is often unique to certain populations. At this time, there have been no reports regarding the role of __BR
Several genes have been involved in the pathogenesis of hereditary breast/ovarian cancer (BOC), but mutations in the BRCA1 gene are by far the most recurrent. In this study, we report the identification of a founder mutation in a geographically and historically homogeneous population from Calabria,