Sixty high-risk breast and/or ovarian cancer families from North-Eastern Poland were screened for germline mutations in BRCA1 (MIM# 113705) and BRCA2 (MIM# 600185), using a combination of protein truncation test, denaturing high-performance liquid chromatography and direct sequencing. Sixteen (27%)
Genetic analysis of BRCA1 and BRCA2 in breast/ovarian cancer families from Aragon (Spain): two novel truncating mutations and a large genomic deletion in BRCA1
✍ Scribed by M. D. Miramar; M. T. Calvo; A. Rodriguez; A. Antón; F. Lorente; E. Barrio; A. Herrero; J. Burriel; A. García de Jalón
- Publisher
- Springer US
- Year
- 2008
- Tongue
- English
- Weight
- 241 KB
- Volume
- 112
- Category
- Article
- ISSN
- 0167-6806
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