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A multicenter evaluation of comprehensive analysis of MLL translocations and fusion gene partners in acute leukemia using the MLL FusionChip device

✍ Scribed by Christine J. Harrison; Mike Griffiths; Fìona Moorman; Susanne Schnittger; Jean-Michel Cayuela; Sheila Shurtleff; Enrico Gottardi; Gerlinde Mitterbauer; Dolores Colomer; Eric Delabesse; Vincent Castéras


Book ID
113513041
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
106 KB
Volume
173
Category
Article
ISSN
0165-4608

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The MLL gene at 11q23 is frequently disrupted by chromosomal translocations in de novo acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), and in secondary leukemia induced by treatment with inhibitors of topoisomerase II, including the epipodophylotoxins. The CBFA2 gene at 21q22 is also