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A diagnostic biochip for the comprehensive analysis of MLL translocations in acute leukemia

✍ Scribed by Maroc, N; Morel, A; Beillard, E; de La Chapelle, A L; Fund, X; Mozziconacci, M-J; Dupont, M; Cayuela, J-M; Gabert, J; Koki, A

Book ID: 110055962
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 327 KB
Volume: 18
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2403439

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The MLL gene at 11q23 is frequently disrupted by chromosomal translocations in de novo acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL), and in secondary leukemia induced by treatment with inhibitors of topoisomerase II, including the epipodophylotoxins. The CBFA2 gene at 21q22 is also