Previous mutational analysis for BRCA gene mutations in sporadic ovarian cancer occurring in Chinese patients in Hong Kong identified six germline BRCA1 mutations and one germline BRCA2 mutation, six of which were novel (Khoo et al., 2000). Knowledge of BRCA gene mutations in the Chinese population
A multi-center study to evaluate the impact of germline BRCA1 and BRCA2 mutations on ovarian cancer survival
β Scribed by KL Bolton; G Chenevix-Trench; C Goh; S Sadetzki; SJ Ramus; SA Gayther; SJ Chanock; AC Antoniou; PDP Pharoah
- Book ID
- 115027782
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 79 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1897-4287
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**Objective and Methods:** In order to explore whether novel genes have been contributing to carcinogenesis of familial ovarian cancer in which no germline mutation of BRCA1 nor BRCA2 is found in the form of a tumor suppressor gene, we have attempted to perform loss of heterozygosity (LOH) analysis
Women harboring BRCA1 germline mutations carry an 85% lifetime risk of developing breast cancer and a 63% risk of ovarian cancer. In this first systematic study of familial breast and/or ovarian cancer in Germany we investigated 29 families for germline mutations in the BRCA1 gene. We identified mut