Anti-DNA autoantibodies are the hallmark of the autoimmune disease systemic lupus erythematosus. Although these antibodies are both diagnostic and pathogenic, little is known about their structures and the manner in which they recognize DNA antigens. To address the first of these points we have pred
A Molecular Model of Braid-like DNA Structure
β Scribed by C.-Q. Liu; C.-L. Bai; Y. Wang; J.-F. Huang; S.-S. Wang; X.-Q. Zhu; E.-H. Cao; J.-S. Zhao
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 419 KB
- Volume
- 177
- Category
- Article
- ISSN
- 0022-5193
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β¦ Synopsis
The three-dimensional molecular models of DNA triple helices and triple-stranded brain-like structure were built up by molecular architecture, and their structural features and energy decomposition were examined. The results showed: (i) The base triplet is the element forming braid-like and triple helix DNA; (ii) Under specified conditions, DNA could form the triplet-stranded braid-like structure; (iii) DNA stability of the braid-like structure is less than that of the triple helix structure.
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