A Molecular Dynamics Model of HIV-1 Reverse Transcriptase Complexed with DNA: Comparison with Experimental Structures
β Scribed by Leping Li; LeeG. Pedersen; WilliamA. Beard; Katarzyna Bebenek; SamuelH. Wilson; ThomasA. Kunkel; ThomasA. Darden
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 360 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1610-2940
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The biological function of HIV-1 integrase (IN) is to integrate viral DNA into the host cell chromosome, and the specific binding of IN with viral DNA is a precondition for IN to function correctly. Beforehand, the binding mode of IN dimer (IN 2 ) with the 27 bp segment of viral DNA before 3' proces
DNA primer/template complex that is needed to obtain a complete view of the NcRTIs mechanism of action.
The conformation of the DNA and the interactions of the nucleic acid with the protein in a complex of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and a 19-mer/18-mer double-stranded DNA template-primer (dsDNA) are described. The structure of this HIV-1 RT complex with dsDN