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A Molecular Dynamics Simulation of Double-Helical B-DNA Including Counterions and Water

โœ Scribed by G. L. Seibel, U. C. Singh and P. A. Kollman


Book ID
123632178
Publisher
National Academy of Sciences
Year
1985
Tongue
English
Weight
695 KB
Volume
82
Category
Article
ISSN
0027-8424

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## Abstract Phosphorothioate oligonucleotides (PSโ€“ODNs) have gained considerable attention in drug therapy, primarily as potent antisense or antigene oligomers, which bind to specific DNA or mRNA sequences and lead to transcriptional or translational arrest. These are obtained by substituting one o