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A Model System to Study Intracellular Trafficking and Processing of the Alzheimer’s Amyloid Precursor Protein

✍ Scribed by da Cruz e Silva, Odete A.B.; Vieira, Sandra Isabel; Rebelo, Sandra; da Cruz e Silva, Edgar F.


Book ID
121014113
Publisher
S. Karger AG
Year
2004
Tongue
English
Weight
422 KB
Volume
1
Category
Article
ISSN
1660-2854

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The main component of the amyloid plaques found in the brains of those with Alzheimer's disease (AD) is a polymerized form of the b-amyloid peptide (Ab) and is considered to play a central role in the pathogenesis of this neurodegenerative disorder. Ab is derived from the proteolytic processing of t