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A model for the binding of lac repressor to the lac operator

✍ Scribed by G. V. Gursky; V. G. Tumanyan; A. S. Zasedatelev; A. L. Zhuze; S. L. Grokhovsky; B. P. Gottikh

Publisher
Springer
Year
1976
Tongue
English
Weight
514 KB
Volume
2
Category
Article
ISSN
0301-4851

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✦ Synopsis

A model is suggested for the lac repressor binding to the lac operator in which the repressor polypeptide chain sequences from Gly 14 to Ala 32 and from Ala 53 to Leu 71 are involved in specific interaction with operator DNA. A correspondence between the protein and DNA sequences is found which explains specificity of the repressor binding to the lac operator. The model can be extended to describe specific binding of other regulatory proteins to DNA.

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## Abstract Carbon‐13 and proton resonance assignments for a DNA fragment complexed with its regulatory protein were obtain with the use of a selectively ^13^C‐labelled oligonucleotide. Data obtained on the Lac operator–Lac repressor complex from the HMQC–NOESY maps of the free and complexed Lac op