✦ LIBER ✦

A model for cadmium transport and distribution in CHO cells

✍ Scribed by T.L. Hayden; J.E. Turner; M.W. Williams; J.S. Cook; A.W. Hsie

Publisher: Elsevier Science
Year: 1982
Tongue: English
Weight: 933 KB
Volume: 15
Category: Article
ISSN: 0010-4809
DOI: 10.1016/0010-4809(82)90030-1

No coin nor oath required. For personal study only.

✦ Synopsis

A compartmental model is developed to study the transport and distribution of cadmium in Chinese hamster ovary (CHO) cells. Of central importance to the model is the role played by sequestering components which bind free Cd*+ ions. The most important of these is a low-molecular-weight protein, metallothionein, which is produced by the cells in response to an increase in the cellular concentration of Cd *+. Monte Carlo techniques are used to generate a stochastic model based on existing experimental data describing the intracellular transport of cadmium between different compartments. This approach provides an alternative to the usual numerical solution of differential-delay equations that arise in deterministic models. Our model suggests subcellular structures which may be re%onsible for the accumulation of cadmium and, hence, could account for cadmium detoxification.

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