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Characteristics and a model for fast axoplasmic transport in nerve

✍ Scribed by Ochs, Sidney

Publisher
John Wiley and Sons
Year
1971
Tongue
English
Weight
899 KB
Volume
2
Category
Article
ISSN
0022-3034

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✦ Synopsis

Fast axoplasmic transport at a characteristic rate close to 400 mm/day is seen in a variety of different mammalian species. Particulates, proteins, polypeptide, and free amino acids are all carried down the fibers at the same rate. An hypothesis to account for such a heterogeneous transport is based on the sliding filament theory of muscle. In the neuron, a "transport filament" is synthesized in the cell body and to it the various transported species are bound. The transporting filament moves down the nerve by means of cross-bridges. In analogy to muscle where ATP is required to supply the energy required for the cross-bridges, fast axoplasmic transport in the nerve fiber also has been found to depend on oxidative metabolism supplying ATP.

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