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A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro

โœ Scribed by Zappulla, David C; Goodrich, Karen; Cech, Thomas R

Book ID
109966403
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
478 KB
Volume
12
Category
Article
ISSN
1545-9993

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## Abstract The minimal vertebrate telomerase enzyme is composed of a protein component (telomerase reverse transcriptase, TERT) and an RNA component (telomerase RNA, TR). Expression of these two subunits is sufficient to reconstitute telomerase activity in vitro, while the formation of a holoenzym