A Mild Method for Regioselective Labeling of Aromatics with Radioactive Iodine
✍ Scribed by Rønnest, Mads H.; Nissen, Felix; Pedersen, Palle J.; Larsen, Thomas O.; Mier, Walter; Clausen, Mads H.
- Book ID
- 120477624
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 262 KB
- Volume
- 2013
- Category
- Article
- ISSN
- 1434-193X
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📜 SIMILAR VOLUMES
The iodination of N-H or N-benzylpyrazoles using elemental iodine in the presence of CAN as the in situ oxidant is a mild and efficient method to prepare 4-iodopyrazoles containing even electron-withdrawing substituents. The reaction is regioselective since the iodine atom preferred pyrazole instead
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A variety of aromatics compounds substituted with methoxy or methyl groups were regioselectively iodinated with N-iodosuccinimide and catalytic trifluoroacetic acid with excellent yields under mild conditions and short reaction times.