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A microRNA-based gene dysregulation pathway in Huntington's disease

✍ Scribed by Rory Johnson; Chiara Zuccato; Nikolai D. Belyaev; Deborah J. Guest; Elena Cattaneo; Noel J. Buckley

Book ID
113812196
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
724 KB
Volume
29
Category
Article
ISSN
0969-9961

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## Abstract Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat region in exon 1 of the HD gene. This mutation results in the presence of an abnormally long polyglutamine tract in the encoded protein, huntingtin (htt). A major question in this fiel