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A method of increasing the sensitivity for laser desorption in an ion trap mass spectrometer

✍ Scribed by G.C. Eiden; M.E. Cisper; M.L. Alexander; P.H. Hemberger; N.S. Nogar

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
369 KB
Volume
4
Category
Article
ISSN
1044-0305

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✦ Synopsis

Laser desorption in an ion trap mass spectrometer shows significant promise for both qualitative and trace analysis. In this work, we explore various combinations of time-varying DC and radiofrequency (RF) fields in order to optimize laser-generated signals. By judicious choice of timing between the laser desorption pulse and the rise in the applied RF trapping potential, we observed over an order of magnitude enhancement in the trapped ion signal. This new method for laser desorption has enabled us to observe mass spectra of many compounds (e.g., pyrene, dichlorobenzene, and ferrocene) that are barely detectable using previous laser desorption methods. Effects of laser timing and the magnitude of the steady-state RF potential are discussed.

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