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A mathematical model for the inhibition of the multidrug resistance-associated P-glycoprotein pump

โœ Scribed by Seth Michelson; Doris Slate

Book ID
112754260
Publisher
Springer
Year
1994
Tongue
English
Weight
935 KB
Volume
56
Category
Article
ISSN
1522-9602

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๐Ÿ“œ SIMILAR VOLUMES

A mathematical model of the P-glycoprote
A mathematical model of the P-glycoprotein pump as a mediator of multidrug resistance
โœ Seth Michelson; Doris Slate ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› Springer ๐ŸŒ English โš– 788 KB

Cells displaying the classic multidrug resistant (MDR) phenotype possess a transmembrane protein (p170 or P-glycoprotein) which can actively extrude cytotoxic agents from the cytoplasm. A mathematical model of this drug efflux pump has been developed. Outward transport is modeled as a facilitated di