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A mathematical model for the inhibition of the multidrug resistance-associated p-glycoprotein pump

✍ Scribed by Seth Michelson; Doris Slate

Book ID
108393290
Publisher
Springer
Year
1994
Tongue
English
Weight
868 KB
Volume
56
Category
Article
ISSN
1522-9602

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πŸ“œ SIMILAR VOLUMES

A mathematical model of the P-glycoprote
A mathematical model of the P-glycoprotein pump as a mediator of multidrug resistance
✍ Seth Michelson; Doris Slate πŸ“‚ Article πŸ“… 1992 πŸ› Springer 🌐 English βš– 788 KB

Cells displaying the classic multidrug resistant (MDR) phenotype possess a transmembrane protein (p170 or P-glycoprotein) which can actively extrude cytotoxic agents from the cytoplasm. A mathematical model of this drug efflux pump has been developed. Outward transport is modeled as a facilitated di

Reversal of multidrug resistance by meth
Reversal of multidrug resistance by methoxypolyethylene glycol-block-polycaprolactone diblock copolymers through the inhibition of P-glycoprotein function
✍ Praveen Elamanchili; Cyrus McEachern; Helen Burt πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 331 KB

Overexpression of P-glycoprotein (Pgp) is one of the major limitations in cancer chemotherapy. Previous work has shown that amphiphilic diblock copolymers composed of methoxypolyethylene glycol-block-polycaprolactone (MePEG-b-PCL) diblock copolymers enhanced the cellular accumulation of Pgp substrat