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A Major Triterpenoid Saponin from Gypsophila oldhamiana

✍ Scribed by Hong Bai; Ying Zhong; Yan-Ying Xie; Yuan-Shu Wang; Lu Liu; Ling Zhou; Ju Wang; Yan-Ling Mu; Chun-Xu Zuo

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
80 KB
Volume
4
Category
Article
ISSN
1612-1872

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✦ Synopsis

Abstract

A new saponin, gypoldoside A (1), was isolated from the roots of Gypsophila oldhamiana. On the basis of in‐depth NMR‐spectroscopic and mass‐spectrometric analysis, in combination with chemical evidence, its structure was established as 3‐O‐{β‐D‐galactopyranosyl‐(1→2)‐[β‐D‐xylopyranosyl‐(1→3)]‐β‐D‐glucuronopyranosyl}quillaic acid 28‐[α‐L‐arabinopyranosyl‐(1→2)‐α‐L‐arabinopyranosyl‐(1→3)‐β‐D‐xylopyranosyl‐(1→4)‐α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐fucopyranosyl] ester. Compound 1 was found to be highly active against three different human cancer cell lines, with IC~50~ values in the low micromolar range.

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