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New Triterpenoid Saponins from the Roots of Gypsophila paniculata L.

✍ Scribed by Shun Yao; Li Ma; Jian-Guang Luo; Jun-Song Wang; Ling-Yi Kong

Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
226 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The seven new triterpenoid saponins 1–7 were isolated from the roots of Gypsophila paniculata L. Their structures were established by 1D‐ and 2D‐NMR techniques, HR‐MS, and acid hydrolysis. The isolated compounds include 3,28‐O‐bidesmosides with or without a 4‐methoxycinnamoyl group (see 1 vs. 2 and 3), and 3‐O‐monoglucosides 4–7. All isolated saponins 1–7 and their aglycones were evaluated for their α‐glucosidase inhibition activity. Compound 1 showed inhibitory activity against yeast α‐glucosidase with an IC~50~ value of 100.9±3.3 μM, whereas compounds 2–7 were inactive.

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✍ Jian-Guang Luo; Ling-Yi Kong 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 96 KB

## Abstract A pair of new oleanane‐type nortriterpene saponin epimers, neogypsoside A (**1**) and B (**2)** (__Fig. 1__) with neogypsogenin A (**3**) and neogypsogenin B (**4**) as the two new aglycons, as well as the two known triterpene saponins **5** and **6** __(Fig. 1__), were isolated from th