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A major role for a 3P21 region and lack of involvement of the t(3;8) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysis

✍ Scribed by P.M.J.F. Veldhuis; A. van den Berg; M.M.F. Hulsbeek; D. de Jong; K. Kok; J. Roche; C.H.C.M. Buys


Book ID
114136519
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
90 KB
Volume
91
Category
Article
ISSN
0165-4608

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In a loss of heterozygosity analysis of 3p, we examined 44 sporadic cases of renal cell carcinoma (RCC) and matched normal tissue with 18 markers distributed over the whole p-arm. The majority of these markers clustered in three regions that have been suggested t o be involved in the development of

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Multiple renal cell tumours from three unrelated patients have been analysed for loss of heterozygosity of 3p, mutation of VHL, and chromosome 7 and 17 imbalances. Loss of 3p alleles is characteristic for clear cell type tumours and the combination of 17, 117 for chromophilic cell type tumours. Thus