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A liquid chromatographic method for the determination of fenoprofen in equine plasma and urine

✍ Scribed by F. T. Delbeke; M. Debackere

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
245 KB
Volume
8
Category
Article
ISSN
0269-3879

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✦ Synopsis

A high performance liquid chromatographic method to measure plasma and urine fenoprofen levels in equine biofluids is described. Liquid-liquid extraction with diethylether was used to isolate the drug from plasma and urine. The accuracy and reproducibility of the method were within acceptable limits over the concentration range 0-10 pg/mL and 0-20 pg/mL respectively from plasma and urine. Detection limits were 0.05 pg/mL (2 mL plasma) and 0.2 pg/mL (0.5 mL urine). This procedure was applied to ascertain the pharmacokinetics of a 3 g dose of fenoprofen calcium in a horse.

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