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A Leu–Lys-rich antimicrobial peptide: activity and mechanism

✍ Scribed by Yoonkyung Park; Dong Gun Lee; Seung-Hwan Jang; Eun-Rhan Woo; Hye Gwang Jeong; Cheol-Hee Choi; Kyung-Soo Hahm

Book ID
108497831
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
623 KB
Volume
1645
Category
Article
ISSN
1570-9639

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Candidacidal mechanism of a Leu/Lys-rich
Candidacidal mechanism of a Leu/Lys-rich α-helical amphipathic model antimicrobial peptide and its diastereomer composed of D,L-amino acids
✍ Peng Wang; Yong Hai Nan; Song Yub Shin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 854 KB

## Abstract We investigated the mechanism of candidacidal action of a Lys/Leu‐rich α‐helical model antimicrobial peptide (K~9~L~8~W) and its diastereomeric peptide (D~9~‐K~9~L~8~W) composed of D,L‐amino acids. K~9~L~8~W killed completely __Candida albicans__ within 30 min, but D~9~‐K~9~L~8~W killed