Mammalian cell toxicity and candidacidal mechanism of Arg- or Lys-containing Trp-rich model antimicrobial peptides and their d-enantiomeric peptides

Candidacidal mechanism of a Leu/Lys-rich

Candidacidal mechanism of a Leu/Lys-rich α-helical amphipathic model antimicrobial peptide and its diastereomer composed of D,L-amino acids

✍ Peng Wang; Yong Hai Nan; Song Yub Shin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 854 KB

## Abstract We investigated the mechanism of candidacidal action of a Lys/Leu‐rich α‐helical model antimicrobial peptide (K~9~L~8~W) and its diastereomeric peptide (D~9~‐K~9~L~8~W) composed of D,L‐amino acids. K~9~L~8~W killed completely __Candida albicans__ within 30 min, but D~9~‐K~9~L~8~W killed