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A less toxic regimen of 5-fluorouracil and high-dose folinic acid for advanced gastrointestinal adenocarcinomas

✍ Scribed by Johnson, PWM; Thompson, PI; Seymour, MT; Deasy, NP; Thuraisingham, RC; Slevin, ML; Wrigley, PFM

Book ID
109836633
Publisher
Nature Publishing Group
Year
1991
Tongue
English
Weight
722 KB
Volume
64
Category
Article
ISSN
0007-0920

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✍ Dennie V. Jones; Roger J. Winn; Barry W. Brown; Lawrence B. Levy; Reginald P. Pu πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 501 KB

Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized