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A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC

✍ Scribed by Pflum, Derek A.; Wilkinson, H. Scott; Tanoury, Gerald J.; Kessler, Donald W.; Kraus, Hali B.; Senanayake, Chris H.; Wald, Stephen A.

Book ID: 111933157
Publisher: American Chemical Society
Year: 2001
Tongue: English
Weight: 68 KB
Volume: 5
Category: Article
ISSN: 1083-6160
DOI: 10.1021/op0002951

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✦ Synopsis

Enantiomerically pure cetirizine can be prepared by preparative HPLC separation of cetirizine amide. The amide has an r value of 2.76 (USP resolution of 8.54) using a Chiralpak AD column, and 0.5 wt % of the amide (based on packing material) can be injected per run.

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