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Convenient, Large-Scale Asymmetric Synthesis of Enantiomerically Pure trans-Cinnamylglycine and -α-Alanine

✍ Scribed by Wei Qiu; Vadim A. Soloshonok; Chaozhong Cai; Xuejun Tang; Victor J. Hruby


Book ID
108370792
Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
145 KB
Volume
56
Category
Article
ISSN
0040-4020

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Convenient, large-scale asymmetric synth
✍ Vadim A Soloshonok; Hironari Ohkura; Alexander Sorochinsky; Natalia Voloshin; An 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 77 KB

The enantiopure p-toluenesulfinimines were found to be efficient as chiral imine equivalents in the high temperature Reformatsky-type additions with BrZnCF 2 COOEt affording an efficient approach to the enantiomerically pure a,a-difluoro-bamino acids. High chemical and stereochemical yields (drs>9:1