A Large Scale Synthesis of a Natural Antibiotic, 2,4-Diacetylophloroglucinol (DAPG)

✍ Scribed by Jerzy Zakrzewski; Monika Karpińska; Zbigniew Maliński

• Book ID: 101645106
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 230 KB
• Volume: 340
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/ardp.200600139

✦ Synopsis

Abstract

A natural antibiotic, 2,4‐diacetylophloroglucinol (DAPG), has been prepared by the acetylation of phloroglucinol (PhL) with acetic anhydride in the presence of boron trifluoride etherate complex. The crude DAPG is efficiently purified using chromatographic filtration with boiling eluent.