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Practical Large-Scale Synthesis of Cefmatilen, A New Cephalosporin Antibiotic

✍ Scribed by Kobayashi, Tatsuya; Masui, Yoshiyuki; Goto, Yoshihisa; Kitaura, Yoji; Mizutani, Taiku; Matsumura, Isao; Sugata, Yoshihide; Ide, Yutaka; Takayama, Masami; Takahashi, Hisanori


Book ID
115480234
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
178 KB
Volume
8
Category
Article
ISSN
1083-6160

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A Large Scale Synthesis of a Natural Ant
✍ Jerzy Zakrzewski; Monika KarpiΕ„ska; Zbigniew MaliΕ„ski πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 230 KB πŸ‘ 1 views

## Abstract A natural antibiotic, 2,4‐diacetylophloroglucinol (DAPG), has been prepared by the acetylation of phloroglucinol (PhL) with acetic anhydride in the presence of boron trifluoride etherate complex. The crude DAPG is efficiently purified using chromatographic filtration with boiling eluent