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A human CD2 minigene directs CRE-mediated recombination in T cells in vivo

✍ Scribed by Trevor J. Wilson; Helen E. Cowdery; Dakang Xu; Ismail Kola; Paul J. Hertzog

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
518 KB
Volume
33
Category
Article
ISSN
1526-954X

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✦ Synopsis

Abstract

Summary: We have produced a mouse line that expresses the Cre recombinase under the regulation of a human CD2 minigene to facilitate Cre‐specific recombination in T lymphocytes. These mice express Cre in thymocytes and T cells and are capable of efficient site‐specific recombination as shown in the spleen and thymus, but not other tissues. These mice thus provide an excellent resource for the study of gene function during thymocyte development and in mature T cells. genesis 33:181–184, 2002. Β© 2002 Wiley‐Liss, Inc.

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