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A human Burkitt’s lymphoma cell line carrying t(8;22) and t(14;18) translocations

✍ Scribed by Thomas Kiefer; Frank Schüler; Agnes Knopp; Maike Wimmer; Carsten Hirt; Hans-Eckart Schaefer; Gottfried Dölken


Publisher
Springer
Year
2007
Tongue
English
Weight
391 KB
Volume
86
Category
Article
ISSN
0939-5555

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The variant translocation t(8;22) in Burkitt's lymphoma (BL) cells joins band q24 of chromosome 8 distal to the proto-oncogene MYC to the immunoglobulin lambda locus. The distribution of breakpoints on chromosome 8 of I I cell lines with t(822) has been investigated by in situ fluorescence hybridiza

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The c-yesl and bcl-2 genes have been independently mapped analysis showed the breakpoint to be at 14q32.3 and 18q21.3 at the same position of the chromosome band, 18q21.3, which [t(14;18) (q32.3;q21.3)] ( Ohno et al., 1985). The FL-18EB is a breakpoint in the t(l4;la) chromosomal translocation. cell

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## Abstract We have analyzed the type of __MYC/IG__ heavy‐chain locus (__IGH__) rearrangement present in 15 patients affected by t(8; 14)‐positive primary Burkitt's lymphoma or acute lymphoblastic leukemia of the L3 type in an attempt to map in detail the locations of the chromosome 8 and chromosom