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Breakpoints of burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC

✍ Scribed by Reinhard Zeidler; Martin Lipp; Stefan Joos; Henri-Jacques Delecluse; Georg W. Bornkamm; Gustav Klobeck; Michele Vuillaume; Gilbert M. Lenoir

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 505 KB
Volume: 9
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870090408

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✦ Synopsis

The variant translocation t(8;22) in Burkitt's lymphoma (BL) cells joins band q24 of chromosome 8 distal to the proto-oncogene MYC to the immunoglobulin lambda locus. The distribution of breakpoints on chromosome 8 of I I cell lines with t(822) has been investigated by in situ fluorescence hybridization and pulsed-field gel electrophoresis. We show that these chromosomal breakpoints generally fall within a region of about 300 kb 3' of MYC and that at least 8 out of I I affect the previously characterized transcriptional unit PVTI. Comparable results were obtained in earlier experiments analyzing the variant t(2;8). Recently, in a series of BL cells carrying t(814), breakpoints upstream of MYC have been described at a similar distance. Therefore, our results suggest that deregulation of MYC by the immunoglobulin loci can occur at a distance of up to about 350 kbp of MYC. Genes Chrorn Cancer 9:282-287 (I 994).

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