HBF 4 -catalyzed Mannich-type reaction of silyl enolates with aldimines took place smoothly in aqueous organic solvent to afford b-aminocarbonyl compounds in high yields. The HBF 4 -catalyzed Mannich-type reaction also proceeded smoothly in water without organic solvent in the presence of a surfacta
A highly stereo-divergent Mannich-type reaction catalyzed by Brønsted acid in aqueous media
✍ Scribed by Takahiko Akiyama; Jun Takaya; Hirotaka Kagoshima
- Book ID
- 104230714
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 98 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A novel cyclic dialkyl phosphate was synthesized starting from (+)‐diethyl tartrate. Its catalytic activity as a chiral Brønsted acid has been examined in the Mannich‐type reaction of a ketene silyl acetal with aldimines as a model reaction. The corresponding β‐amino acid esters were ob