## Abstract The highly enantioselective organocatalytic domino aza‐Michael/aldol reaction is presented. The unprecedented, chiral amine‐catalyzed asymmetric domino reactions between 2‐aminobenzaldehydes and α,β‐unsaturated aldehydes proceed with excellent chemo‐ and enantioselectivity to give the c
✦ LIBER ✦
A Highly Enantioselective Catalytic Domino Aza-Michael/Aldol Reaction: One-Pot Organocatalytic Asymmetric Synthesis of 1,2-Dihydroquinolidines.
✍ Scribed by Henrik Sunden; Ramon Rios; Ismail Ibrahem; Gui-Ling Zhao; Lars Eriksson; Armando Cordova
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 28 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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## Abstract An enantioselective oxa‐Michael–Henry reaction of substituted salicylaldehydes with nitroolefins that proceeds though an aromatic iminium activation (AIA) has been developed by using a chiral secondary amine organocatalyst and salicylic acid as a co‐catalyst. The corresponding 3‐nitro‐2