Asymmetric Organocatalytic Domino Michael/Aldol Reactions: Enantioselective Synthesis of Chiral Cycloheptanones, Tetrahydrochromenones, and Polyfunctionalized Bicyclo[3.2.1]octanes

A Highly Enantioselective Catalytic Domi

A Highly Enantioselective Catalytic Domino Aza-Michael/Aldol Reaction: One-Pot Organocatalytic Asymmetric Synthesis of 1,2-Dihydroquinolidines

✍ Henrik Sundén; Ramon Rios; Ismail Ibrahem; Gui-Ling Zhao; Lars Eriksson; Armando 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB 👁 2 views

## Abstract The highly enantioselective organocatalytic domino aza‐Michael/aldol reaction is presented. The unprecedented, chiral amine‐catalyzed asymmetric domino reactions between 2‐aminobenzaldehydes and α,β‐unsaturated aldehydes proceed with excellent chemo‐ and enantioselectivity to give the c