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A genetic model having complex linkage behaviour

✍ Scribed by W. J. Ewens

Book ID: 105010128
Publisher: Springer
Year: 1968
Tongue: English
Weight: 362 KB
Volume: 38
Category: Article
ISSN: 0040-5752
DOI: 10.1007/bf00933808

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Results from the study by Sherrington et a]. [1988] indicate that the maximum lod score (3.2) from a linkage analysis between narrowly defined clinical diagnostic criteria for schizophrenia and polymorphic markers on chromosome 5 is lower than that (6.5) from an analogous analysis between broadly de

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✍ Elliot S. Gershon 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 229 KB

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✍ Philip Green 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB

For diseases with a complex mode of inheritance, such as schizophrenia, traditional linkage analysis assuming Mendelian inheritance of a single gene may be expected to have relatively low power, but to occasionally detect (in fortuitous pedigree samples) either a rare gene which by itself causes the

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✍ Steven Matthysse 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 176 KB

I should like to make four points in connection with Neil Risch's [ 19901 provocative and thoughtful review.

Genetic linkage and complex diseases: A

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✍ Newton E. Morton 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 140 KB

A linkage test in complex disease is well motivated under either of two conditions: if a prior segregation analysis has given evidence for a major gene, or if there is a candidate locus that may influence liability. Although methods have been developed for pairs of affected relatives without specify

Genetic linkage and complex diseases: A

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✍ Jurg Ott 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB

Dr. Risch [ 19901 is to be commended for his authoritative investigation and review of the many potential problems associated with linkage analysis of complex diseases. Such a comprehensive report has long been due. Here, I would like to expand on a technique briefly referred to towards the end of t