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A General Synthesis of 1-Aryl Carbamoyl-2-alkyl-4-aryl Substituted Semicarbazides as Nonbasic Factor Xa Inhibitors.

✍ Scribed by Werner W. K. R. Mederski; Martina Germann


Publisher
John Wiley and Sons
Year
2004
Weight
97 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract 1‐(Aralkyl/aryl)‐3‐(alkyyaralkyl)‐5‐aroyl‐1,2,3,4‐tetrahydropyrimidines (**2a‐c**) have been synthesized by dethiomethylation of 5‐aroyl‐6‐methylthio‐1,2,3,4‐tetrahydropyrimidines (**1a‐c**). An alternative one‐pot synthetic strategy has been developed for the title compounds **2a‐t** b