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New efficient approach for the synthesis of 2-alkyl(aryl) substituted 4H-pyrido[1,2-a]pyrimidin-4-ones

✍ Scribed by Helio G. Bonacorso; Fernando J. Righi; Isadora R. Rodrigues; Cleber A. Cechinel; Michelle B. Costa; Arci D. Wastowski; Marcos A. P. Martins; Nilo Zanatta

Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
79 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis

in 45 -80 % yield from the reaction of β-alkoxyvinyl trichloromethyl ketones with 2-aminopyridine under mild conditions, is then reported.

📜 SIMILAR VOLUMES

Substituted pyridopyrimidinones, 1: Conv
Substituted pyridopyrimidinones, 1: Convenient PTC alkylation and halogenation of 2-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one
✍ Mohamed Abass; Aisha S. Mayas 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 173 KB

## Abstract Alkylation of 2‐hydroxy‐4__H__‐pyrido[1,2‐__a__]pyrimidin‐4‐one (**1**) was investigated under solid–liquid phase transfer catalysis conditions (PTC), using tetrabutylammonium bromide and potassium carbonate. The reaction with alkyl halides led to the formation of various 2‐alkoxy produ

Condensation of substituted 2-aminopyrid
Condensation of substituted 2-aminopyridine with β-ketocarboxylic esters: 4H-pyrido[1,2-a]pyrimidin-4-ones and pyridin-2-ones
✍ Pier Luigi Ferrarini; Claudio Mori; Clementina Manera; Filippo Mori; Vincenzo Ca 📂 Article 📅 1999 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 268 KB

## Abstract We report the condensation of substituted 2‐aminopyridines 5 with β‐ketocarboxylic esters in polyphosphoric acid. In this reaction were obtained together with the target compounds, 4__H__‐pyrido[1,2‐__a__]pyrirnidin‐4‐ones 6 also the pyridin‐2‐ones 7. All the compounds 7 were tested for

ChemInform Abstract: A New, One-Pot, Thr
ChemInform Abstract: A New, One-Pot, Three-Component Synthesis of 4H-Pyrido[1,2-a]pyrimidines, 4H-Pyrimido[1,2-a]pyrimidines, and 4H-Pyrazino[1,2-a]pyrimidines.
✍ Mehdi Adib; Mohammad Hosein Sayahi; Hakimeh Ziyadi; Hamid Reza Bijanzadeh; Long- 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v