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Condensation of substituted 2-aminopyridine with β-ketocarboxylic esters: 4H-pyrido[1,2-a]pyrimidin-4-ones and pyridin-2-ones

✍ Scribed by Pier Luigi Ferrarini; Claudio Mori; Clementina Manera; Filippo Mori; Vincenzo Calderone; Enrica Martinotti

Publisher: Journal of Heterocyclic Chemistry
Year: 1999
Tongue: English
Weight: 268 KB
Volume: 36
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570360502

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✦ Synopsis

Abstract

We report the condensation of substituted 2‐aminopyridines 5 with β‐ketocarboxylic esters in polyphosphoric acid. In this reaction were obtained together with the target compounds, 4__H__‐pyrido[1,2‐a]pyrirnidin‐4‐ones 6 also the pyridin‐2‐ones 7. All the compounds 7 were tested for their calcium‐antagonistic activity but failed to evoke any vasorelaxant response.

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