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A general stereospecific synthesis of γ-hydroxy-α,β-unsaturated esters

✍ Scribed by L. Thijs; F.J. Dommerholt; F.M.C. Leemhuis; B. Zwanenburg


Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
258 KB
Volume
31
Category
Article
ISSN
0040-4039

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Synthesis of γ-Hydroxy-α,β-unsaturated E
✍ Jan Marcus; Pauline J. van Meurs; Adrianus M.C.H. van den Nieuwendijk; Mathieu P 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 145 KB

The Horner-Wittig reaction of cyanomethyl-and carbethoxymethyl diphenylphosphine oxides with a range of O-protected chiral a-hydroxy aldehydes is described. The a-hydroxy aldehydes were prepared with high enantiomeric purity from chiral O-protected cyanohydrins. The g-hydroxy-a,b-unsaturated compoun