A general route to 4-substituted imidazoles
✍ Scribed by Katritzky, Alan R.; Slawinski, Jaroslaw J.; Brunner, Fr�d�ric; Gorun, Sergiu
- Book ID
- 115455416
- Publisher
- Royal Society of Chemistry
- Year
- 1989
- Weight
- 879 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1472-7781
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## Abstract A new synthetic route to 4‐substituted‐2,2′‐bithiophenes has been developed utilizing 4‐bromo‐2,2′‐bithiophene (1). Formation of the bithienyllithium adduct __via__ halogen‐metal exchange was found to be problematic and resulted in complex mixtures of products. The Grignard reagent of 1
Grignard reagents react with 7-oxabicycloC2.2.llhept-5-ene-2,3-dicarboxylic anhydride and produce in high yields the corresponding substituted bicycle-y-butanolides. These lactones produce the title compounds by retro Diels-Alder reaction during distillation. Previously, we have demonstrated that th