✦ LIBER ✦

A facile and general route to 4-substituted-2 butenolides

✍ Scribed by Persephone Canonne; Mohamed Akssira; Gilles Lemay

Book ID: 104244065
Publisher: Elsevier Science
Year: 1981
Tongue: French
Weight: 222 KB
Volume: 22
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)92950-8

No coin nor oath required. For personal study only.

✦ Synopsis

Grignard reagents react with 7-oxabicycloC2.2.llhept-5-ene-2,3-dicarboxylic anhydride and produce in high yields the corresponding substituted bicycle-y-butanolides. These lactones produce the title compounds by retro Diels-Alder reaction during distillation. Previously, we have demonstrated that the action of di(bromomagnesio)alkanes with dicarboxylic cyclic anhydrides gave the corresponding spirolactones.'*' In a one-step reaction, this methodology was found to be general to most anhydrides with the exception of maleic anhydride which gave a mixture of several compounds.3 We describe herein a new and important aspect of this methodology which permits the synthesis of a series of bicyclobutanolides.

📜 SIMILAR VOLUMES

A general synthetic route to 4-substitut

A general synthetic route to 4-substituted-2,2′-bithiophenes

✍ Seth C. Rasmussen; Jason C. Pickens; James E. Hutchison 📂 Article 📅 1997 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 341 KB

## Abstract A new synthetic route to 4‐substituted‐2,2′‐bithiophenes has been developed utilizing 4‐bromo‐2,2′‐bithiophene (1). Formation of the bithienyllithium adduct __via__ halogen‐metal exchange was found to be problematic and resulted in complex mixtures of products. The Grignard reagent of 1

A General Route to 4-C-Substituted Pyrim

A General Route to 4-C-Substituted Pyrimidine Nucleosides.

✍ Ulrich Hennecke; David Kuch; Thoms Carell 📂 Article 📅 2007 🏛 John Wiley and Sons ⚖ 38 KB 👁 1 views

A facile route to 2-substituted N-Boc py

A facile route to 2-substituted N-Boc pyrrolidines

✍ Alan R Katritzky; Zhushou Luo; Yunfeng Fang 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 45 KB

ChemInform Abstract: A General Synthetic

ChemInform Abstract: A General Synthetic Route to 4-Substituted-2,2′-bithiophenes.

✍ S. C. RASMUSSEN; J. C. PICKENS; J. E. HUTCHISON 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 28 KB 👁 2 views

A Facile, General Route to Bridge-Annela

A Facile, General Route to Bridge-Annelated [2.2]Paracyclophanedienes

✍ Dipl.-Chem. Oliver Reiser; Stefen Reichow; Prof. Dr. Armin de Meijere 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB 👁 2 views

ChemInform Abstract: A Facile and Versat

ChemInform Abstract: A Facile and Versatile Route to 2-Substituted-4(3H)-quinazolinones and Quinazolines.

✍ David J. Connolly; Patrick J. Guiry 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v