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A general approach to site-specific antibody drug conjugates

✍ Scribed by Tian, Feng; Lu, Yingchun; Manibusan, Anthony; Sellers, Aaron; Tran, Hon; Sun, Ying; Phuong, Trung; Barnett, Richard; Hehli, Brad; Song, Frank; DeGuzman, Michael J.; Ensari, Semsi; Pinkstaff, Jason K.; Sullivan, Lorraine M.; Biroc, Sandra L.; Cho, Ho; Schultz, Peter G.; DiJoseph, John; Dougher, Maureen; Ma, Dangshe; Dushin, Russell; Leal, Mauricio; Tchistiakova, Lioudmila; Feyfant, Eric; Gerber, Hans-Peter; Sapra, Puja


Book ID
126977870
Publisher
National Academy of Sciences
Year
2014
Tongue
English
Weight
865 KB
Volume
111
Category
Article
ISSN
0027-8424

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✍ S. Pochon; F. Buchegger; A. PΓ©legrin; J.-P. Mach; R. E. Offord; J. E. Ryser; K. πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 896 KB

We describe the preparation of the modified chelator aminooxyacetyl-ferrioxamine, and the replacement of i t s iron atom by 67Ga at high specific activity. The aminooxy function of this compound was allowed to react with the aldehyde groups generated by the periodate oxidation of the oligosaccharide