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Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

✍ Scribed by Junutula, Jagath R; Raab, Helga; Clark, Suzanna; Bhakta, Sunil; Leipold, Douglas D; Weir, Sylvia; Chen, Yvonne; Simpson, Michelle; Tsai, Siao Ping; Dennis, Mark S


Book ID
109900621
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
357 KB
Volume
26
Category
Article
ISSN
1087-0156

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A novel derivative of the chelon desferr
✍ S. Pochon; F. Buchegger; A. PΓ©legrin; J.-P. Mach; R. E. Offord; J. E. Ryser; K. πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 French βš– 896 KB

We describe the preparation of the modified chelator aminooxyacetyl-ferrioxamine, and the replacement of i t s iron atom by 67Ga at high specific activity. The aminooxy function of this compound was allowed to react with the aldehyde groups generated by the periodate oxidation of the oligosaccharide