Site-Specific Trastuzumab Maytansinoid Antibody–Drug Conjugates with Improved Therapeutic Activity through Linker and Antibody Engineering

✍ Scribed by Pillow, Thomas H.; Tien, Janet; Parsons-Reponte, Kathryn L.; Bhakta, Sunil; Li, Hao; Staben, Leanna R.; Li, Guangmin; Chuh, Josefa; Fourie-O’Donohue, Aimee; Darwish, Martine; Yip, Victor; Liu, Luna; Leipold, Douglas D.; Su, Dian; Wu, Elmer; Spencer, Susan D.; Shen, Ben-Quan; Xu, Keyang; Kozak, Katherine R.; Raab, Helga; Vandlen, Richard; Lewis Phillips, Gail D.; Scheller, Richard H.; Polakis, Paul; Sliwkowski, Mark X.; Flygare, John A.; Junutula, Jagath R.

• Book ID: 126903108
• Publisher: American Chemical Society
• Year: 2014
• Tongue: English
• Weight: 533 KB
• Volume: 57
• Category: Article
• ISSN: 0022-2623
• DOI: 10.1021/jm500552c