The anthracycline antibiotics adriamycin(3 and daunorubicin(8 are of current interest because of their activity against various experimental tumors as well as certain types of human cancer.') Studies on the structure-activity relationship have revealed that 4-demethoxy analogues of !, and g show imp
A general and highly efficient asymmetric synthesis of optically active anthracyclinones
โ Scribed by Michiyo Suzuki; Yoshikazu Kimura; Shiro Terashima
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- French
- Weight
- 274 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
โฆ Synopsis
The title asymmetric synthesis has been OF OPTICALLY ACTIVE ANTHRACYCLINONES' and Shiro Terashima*
๐ SIMILAR VOLUMES
There have been developed several kinds of asymmetric syntheses for preparing optically active a-hydroxy acids, ') and high optical induction(>80% e.e.) can be successfully achieved by selecting chiral sources lb) or by
We are grateful to the Fonds der Chemischen Industrie for financial support, and S.-M.L. thanks the Alexander von Humboldt Foundation for a postdoctoral fellowship. We also acknowledge Dr. C. Jaekel (BASF AG) for pointing out Refs. [5h] and [6].