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An efficient synthesis of optically active 4-demethoxy anthracyclinones

โœ Scribed by Fatima Bennani; Jean-Claude Florent; Michel Koch; Claude Monneret


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
197 KB
Volume
25
Category
Article
ISSN
0040-4039

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The anthracycline antibiotics adriamycin(3 and daunorubicin(8 are of current interest because of their activity against various experimental tumors as well as certain types of human cancer.') Studies on the structure-activity relationship have revealed that 4-demethoxy analogues of !, and g show imp