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A gene–environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis

✍ Scribed by Julia M. Morahan; Bing Yu; Ronald J. Trent; Roger Pamphlett

Book ID
116779793
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
184 KB
Volume
28
Category
Article
ISSN
0161-813X

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## Abstract Three clustered, homologous paraoxonase genes (__PON1__, __PON2,__ and __PON3__) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the __PON__ genes and sporadic amyotrophic lateral sclerosis (ALS). We now re