Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis
β Scribed by Wu, Chi-Hong; Fallini, Claudia; Ticozzi, Nicola; Keagle, Pamela J.; Sapp, Peter C.; Piotrowska, Katarzyna; Lowe, Patrick; Koppers, Max; McKenna-Yasek, Diane; Baron, Desiree M.; Kost, Jason E.; Gonzalez-Perez, Paloma; Fox, Andrew D.; Adams, Jenni; Taroni, Franco; Tiloca, Cinzia; Leclerc, Ashley Lyn; Chafe, Shawn C.; Mangroo, Dev; Moore, Melissa J.; Zitzewitz, Jill A.; Xu, Zuo-Shang; van den Berg, Leonard H.; Glass, Jonathan D.; Siciliano, Gabriele; Cirulli, Elizabeth T.; Goldstein, David B.; Salachas, Francois; Meininger, Vincent; Rossoll, Wilfried; Ratti, Antonia; Gellera, Cinzia; Bosco, Daryl A.; Bassell, Gary J.; Silani, Vincenzo; Drory, Vivian E.; Brown Jr, Robert H.; Landers, John E.
- Book ID
- 118117524
- Publisher
- Nature Publishing Group
- Year
- 2012
- Tongue
- English
- Weight
- 1020 KB
- Volume
- 488
- Category
- Article
- ISSN
- 0028-0836
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## Abstract Three clustered, homologous paraoxonase genes (__PON1__, __PON2,__ and __PON3__) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the __PON__ genes and sporadic amyotrophic lateral sclerosis (ALS). We now re