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Novel mutation in VCP gene causes atypical amyotrophic lateral sclerosis

✍ Scribed by Gonzalez-Perez, P.; Cirulli, E. T.; Drory, V. E.; Dabby, R.; Nisipeanu, P.; Carasso, R. L.; Sadeh, M.; Fox, A.; Festoff, B. W.; Sapp, P. C.; McKenna-Yasek, D.; Goldstein, D. B.; Brown, R. H.; Blumen, S. C.


Book ID
118046372
Publisher
Lippincott Williams and Wilkins
Year
2012
Tongue
English
Weight
451 KB
Volume
79
Category
Article
ISSN
0028-3878

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## Abstract Three clustered, homologous paraoxonase genes (__PON1__, __PON2,__ and __PON3__) have roles in preventing lipid oxidation and detoxifying organophosphates. Recent reports describe a genetic association between the __PON__ genes and sporadic amyotrophic lateral sclerosis (ALS). We now re